Abstract
Abstract
Purpose: The purpose of this study was to compare the target coverage and dose to heart, LADCA and ipsilateral lung, when planning with protons instead of
photons for breast cancer patients with IMN irradiation. In connection with this, a proton treatment planning strategy was developed.
Material and methods: The CT-scans of 8 women from the research project SKAGEN was included. All patients had received photon radiation treatment with
inclusion of IMN and treated in DIBH. Comparative proton plans were generated with the use of PBS technique, 2 anterior fields using SFO, 10 cm air gap
and 5 cm range shifter. Robust optimization and evaluation were made on the CTV. The DVH of both plans were used to compare.
Results: The proton plans showed a higher coverage of the CTVn and CTVp with a D95% of respectively 98.49 % and 98.36 % of the prescribed dose, where the photon plans showed an average D95% of 94.32 % and 96.24 % of the prescribed dose. In most patients, the mean dose to OAR was lower with the use of protons. The treatment planning strategy was viable for 7 patients out of 8.
Conclusion: The use of protons points towards being a useful treatment for these patients, by providing radiation treatment including IMN irradiation, without compromising target coverage and simultaneously providing a lower dose to the OAR for most patients. The suggested treatment planning strategy is applicable for 7 out of 8 included patients and provide a basis for further research.
Purpose: The purpose of this study was to compare the target coverage and dose to heart, LADCA and ipsilateral lung, when planning with protons instead of
photons for breast cancer patients with IMN irradiation. In connection with this, a proton treatment planning strategy was developed.
Material and methods: The CT-scans of 8 women from the research project SKAGEN was included. All patients had received photon radiation treatment with
inclusion of IMN and treated in DIBH. Comparative proton plans were generated with the use of PBS technique, 2 anterior fields using SFO, 10 cm air gap
and 5 cm range shifter. Robust optimization and evaluation were made on the CTV. The DVH of both plans were used to compare.
Results: The proton plans showed a higher coverage of the CTVn and CTVp with a D95% of respectively 98.49 % and 98.36 % of the prescribed dose, where the photon plans showed an average D95% of 94.32 % and 96.24 % of the prescribed dose. In most patients, the mean dose to OAR was lower with the use of protons. The treatment planning strategy was viable for 7 patients out of 8.
Conclusion: The use of protons points towards being a useful treatment for these patients, by providing radiation treatment including IMN irradiation, without compromising target coverage and simultaneously providing a lower dose to the OAR for most patients. The suggested treatment planning strategy is applicable for 7 out of 8 included patients and provide a basis for further research.
| Bidragets oversatte titel | En protonbehandlingsstrategi for c. mammae patienter med involvering af IMN |
|---|---|
| Originalsprog | Engelsk |
| Publikationsdato | 22 maj 2019 |
| Status | Udgivet - 22 maj 2019 |