Overlevere efter cancer hos børn og unge - Risiko for at modtage førtidspension som voksne.

Publikation: Ph.d. afhandling/ kandidat/ diplomKandidatspecialeForskning

Abstract

Abstract
Adult survivors of childhood cancer
- Risk of receiving a disability pension
Purpose
This population based cohort study assessed the effect of cancer exposure in childhood
and adolescence measured as risk of receiving a disability pension as adults. The effect
of exposure to different cancer types was also measured.
Patients and Methods
A group of 3364 adult survivors from childhood cancer, born 1960-1987 and diagnosed
before the age of 20 years were identified from the nationwide Danish Cancer registry. A
total of 67 280 ages- and sex matched comparison persons with no history of cancer
before the age of 20 years were randomly chosen from the general population by
Statistics Denmark. Differences in risks of disability pension, calculated as Hazard ratios
(HR), were established between cohorts for “survivors” versus “comparison persons”
and within cohort for survivors from “CNS tumours” and “other cancers” versus
survivors from “haematological cancer”. Follow-up started at the age of 20 years and
was assessed for the period 1984-2007.
Results
Survivors had a risk of 7.1 (95% CI 6.4-7.8) times the risk among comparison persons
for receiving a disability pension. Within cohort comparisons of survivors showed that
survivors from CNS tumours had a risk of 5.1 (95% CI 3.9-6.5) and survivors from other
cancers had a risk of 1.4 (95% CI 1.0-1.8) times the risk in haematological cancers for
receiving a disability pension.
Neither sex nor year of birth was significantly associated to the risk of disability pension.
Children diagnosed in preschool age (0-7 years) with CNS tumours had twice the risk of
receiving disability pension as children and adolescents diagnosed 8-19 years of age (HR
8.4 (95% CI 5.4-13.0) and 3.9 (95% CI 2.8-5.2), respectively).
Conclusion
Cancer exposure in childhood or adolescence led to considerable increase in risk of
receiving a disability pension as adult. Highest risk for receiving a disability pension was
seen among survivors from CNS tumours and lowest risk was seen in survivors from
haematological cancers. Diagnosis in preschool age doubled the risk of becoming a
disability pensioner for survivors from CNS tumours.
Bidragets oversatte titelOverlevere efter cancer hos børn og unge - Risiko for at modtage førtidspension som voksne.
OriginalsprogEngelsk
KvalifikationCand.scient.
Vejledere/rådgivere
  • Asdahl, Peter, Vejleder, Ekstern person
  • Hasled, Henrik, Vejleder, Ekstern person
StatusUdgivet - 30 jun. 2015
Udgivet eksterntJa

Emneord

  • kræft

Citationsformater