Alzheimer transgenic models

R Folkesson, B Winblad, E Benedikz

Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review


Purpose of review A number of Alzheimer transgenic mouse models have been generated using a variety of different constructs containing the amyloid precursor protein. Some of the models develop features of Alzheimer's disease, including amyloid pathology, cholinergic deficits and cognitive impairment. Recent publications have demonstrated the benefits of using transgenic animals as models of Alzheimer's disease. transgenes relevant to Alzheimer's disease have enhanced our understanding of the underlying pathogenic mechanisms. In the past year the Alzheimer transgenic models have increasingly been used in the development of anti-Alzheimer drugs. complete models of Alzheimer's disease, they are useful for studies on pathogenic mechanisms and the evaluation of new anti-amyloid treatment strategies. [References: 48]
TidsskriftCurrent Opinion in Psychiatry
Udgave nummer4
Sider (fra-til)433-439
Antal sider7
StatusUdgivet - 2002
Udgivet eksterntJa