Antibodies to Epstein-Barr virus and neurotropic viruses in multiple sclerosis and optic neuritis

Gunnar Houen, Julie Heiden, Nicole H Trier, Anette H Draborg, Michael E Benros, Rūta Zinkevičiūtė, Rasa Petraitytė-Burneikienė, Evaldas Ciplys, Rimantas Slibinskas, Jette L Frederiksen

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Antibody indices to Measles, Mumps, Varicella Zoster (MRZ) are of diagnostic value in multiple sclerosis (MS). Here, we have investigated, if this panel could be extended to increase diagnostic value. Samples from relapsing-remitting (RR) MS and optic neuritis (ON) patients were tested for reactivity to antigens from Epstein-Barr, Varicella Zoster, Measles, Mumps and Rubella (EMMRZ) viruses. Increased IgG levels in serum and cerebrospinal fluid (CSF) were found in RRMS patients, along with a significant correlation between serum and CSF. The sensitivity of the EMMRZ panel was increased approximately 40% compared to the MRZ panel, suggesting that the EMMRZ panel may be useful in MS and ON diagnostics.

TidsskriftJournal of Neuroimmunology
Sider (fra-til)577314
StatusE-pub ahead of print - 7 jul. 2020
Udgivet eksterntJa