@article{837e474e81ed4ad3a3092a7e0d443bcc,
title = "Arabidopsis map kinase 4 negatively regulates systemic acquired resistance",
abstract = "Transposon inactivation of Arabidopsis MAP kinase 4 produced the mpk4 mutant exhibiting constitutive systemic acquired resistance (SAR) including elevated salicylic acid (SA) levels, increased resistance to virulent pathogens, and constitutive pathogenesis-related gene expression shown by Northern and microarray hybridizations. MPK4 kinase activity is required to repress SAR, as an inactive MPK4 form failed to complement mpk4. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression.",
keywords = "Alleles, Arabidopsis, Arabidopsis Proteins, Blotting, Northern, Cold Temperature, Cyclopentanes, Desiccation, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Hot Temperature, Immunity, Innate, Mutation, Oxylipins, Plant Diseases, Plant Growth Regulators, Plant Proteins, Protein Tyrosine Phosphatases, Pseudomonas, Pseudomonas Infections, RNA, Messenger, Salts, Transcriptional Activation",
author = "P Brodersen and Bo Johansen and M Petersen and H Naested and E Andreasson and U Lindhart and Nielsen, {H B} and M Lacy and Austin, {M J} and Parker, {J E} and Sharma, {S B} and Klessig, {D F} and R Martienssen and O Mattsson and Jensen, {A B} and J Mundy",
note = "Funding Information: Xinnian Dong is thanked for npr1-1 and cpr1 seed, and the Arabidopsis Biological Resource Center is thanked for DNA stocks. Ying Kaaring and Suksawad Vongvisutikkun are thanked for technical help. This work was supported by grants to J. M. from the European Union (QLG2-1999-00351) and Danish Biotechnology Program (9602416), to J. E. P. from the Gatsby Charitable Foundation, and to D. F. K. from the U. S. Department of Agriculture (98353036664) and National Science Foundation (MCB9723952).",
year = "2000",
month = dec,
day = "22",
doi = "10.1016/S0092-8674(00)00213-0",
language = "English",
volume = "103",
pages = "1111--1120",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",
}