Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT: Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Carsten Ammitzbøl Lauridsen, Rie Østbjerg Eriksen, Louise Søborg Strauch, Michael Bachmann Nielsen, Thomas Skaarup Kristensen, Michael Sandgaard

    Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

    Abstract

    The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies.
    OriginalsprogEngelsk
    Artikelnummer130846
    TidsskriftDiagnostics
    Vol/bind6
    Udgave nummer3
    Sider (fra-til)0-17
    Antal sider17
    ISSN2075-4418
    DOI
    StatusUdgivet - 21 jul. 2016

    Emneord

    • Kliniske undersøgelsesmetoder, laboratorieteknologi og radiografi
    • radiografi

    Citationsformater