TY - JOUR
T1 - Brain structure associations with phonemic and semantic fluency in typically-developing children
AU - Gonzales, Marybel Robledo
AU - Baaré, William Frans Christian
AU - Hagler Jr,, Donald J.
AU - Archibald, Sarah
AU - Vestergaard, Martin
AU - Madsen, Kathrine Skak
N1 - Publisher Copyright: © 2021
PY - 2021/8
Y1 - 2021/8
N2 - Verbal fluency is the ability to retrieve lexical knowledge quickly and efficiently and develops during childhood and adolescence. Few studies have investigated associations between verbal fluency performance and brain structural variation in children. Here we examined associations of verbal fluency performance with structural measures of frontal and temporal language-related brain regions and their connections in 73 typically-developing children aged 7–13 years. Tract-based spatial statistics was used to extract fractional anisotropy (FA) from the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and the white matter underlying frontal and temporal language-related regions. FreeSurfer was used to extract cortical thickness and surface area. Better semantic and phonemic fluency performance was associated with higher right SLF/AF FA, and phonemic fluency was also modestly associated with lower left SLF/AF FA. Explorative voxelwise analyses for semantic fluency suggested associations with FA in other fiber tracts, including corpus callosum and right inferior fronto-occipital fasciculus. Overall, our results suggest that verbal fluency performance in children may rely on right hemisphere structures, possibly involving both language and executive function networks, and less on solely left hemisphere structures as often is observed in adults. Longitudinal studies are needed to clarify whether these associations are mediated by maturational processes, stable characteristics and/or experience.
AB - Verbal fluency is the ability to retrieve lexical knowledge quickly and efficiently and develops during childhood and adolescence. Few studies have investigated associations between verbal fluency performance and brain structural variation in children. Here we examined associations of verbal fluency performance with structural measures of frontal and temporal language-related brain regions and their connections in 73 typically-developing children aged 7–13 years. Tract-based spatial statistics was used to extract fractional anisotropy (FA) from the superior longitudinal fasciculus/arcuate fasciculus (SLF/AF), and the white matter underlying frontal and temporal language-related regions. FreeSurfer was used to extract cortical thickness and surface area. Better semantic and phonemic fluency performance was associated with higher right SLF/AF FA, and phonemic fluency was also modestly associated with lower left SLF/AF FA. Explorative voxelwise analyses for semantic fluency suggested associations with FA in other fiber tracts, including corpus callosum and right inferior fronto-occipital fasciculus. Overall, our results suggest that verbal fluency performance in children may rely on right hemisphere structures, possibly involving both language and executive function networks, and less on solely left hemisphere structures as often is observed in adults. Longitudinal studies are needed to clarify whether these associations are mediated by maturational processes, stable characteristics and/or experience.
KW - Category fluency
KW - Diffusion tensor imaging
KW - Letter fluency
KW - MRI
KW - Surface area
KW - superior longitudinal fasciculus
UR - http://www.scopus.com/inward/record.url?scp=85108344742&partnerID=8YFLogxK
U2 - 10.1016/j.dcn.2021.100982
DO - 10.1016/j.dcn.2021.100982
M3 - Journal article
SN - 1878-9293
VL - 50
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
IS - August
M1 - 100982
ER -