Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women

M L Østerdal, M Strøm, A K Klemmensen, V K Knudsen, M Juhl, T I Halldorsson, A-M Nybo Andersen, P Magnus, S F Olsen

Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review


OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.

DESIGN: Prospective cohort.

SETTING: Denmark.

POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.

METHODS: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.

MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia.

RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).

CONCLUSIONS: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

TidsskriftBJOG : an international journal of obstetrics and gynaecology
Udgave nummer1
Sider (fra-til)98-107
Antal sider10
StatusUdgivet - jan. 2009