Does leisure time physical activity in early pregnancy protect against pre-eclampsia?: Prospective cohort in Danish women

M L Østerdal; M Strøm; A K Klemmensen; V K Knudsen; M Juhl; T I Halldorsson; A-M Nybo Andersen; P Magnus; S F Olsen

doi:10.1111/j.1471-0528.2008.02001.x

Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women

M L Østerdal, M Strøm, A K Klemmensen, V K Knudsen, M Juhl, T I Halldorsson, A-M Nybo Andersen, P Magnus, S F Olsen

Statens Serum Institut

Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

Abstract

OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.

DESIGN: Prospective cohort.

SETTING: Denmark.

POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.

METHODS: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.

MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia.

RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).

CONCLUSIONS: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

Originalsprog	Engelsk
Tidsskrift	BJOG : an international journal of obstetrics and gynaecology
Vol/bind	116
Udgave nummer	1
Sider (fra-til)	98-107
Antal sider	10
ISSN	1470-0328
DOI	https://doi.org/10.1111/j.1471-0528.2008.02001.x
Status	Udgivet - jan. 2009

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10.1111/j.1471-0528.2008.02001.xLicens: CC BY

Citationsformater

Østerdal, M. L., Strøm, M., Klemmensen, A. K., Knudsen, V. K., Juhl, M., Halldorsson, T. I., Nybo Andersen, A.-M., Magnus, P., & Olsen, S. F. (2009). Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women. BJOG : an international journal of obstetrics and gynaecology, 116(1), 98-107. https://doi.org/10.1111/j.1471-0528.2008.02001.x

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title = "Does leisure time physical activity in early pregnancy protect against pre-eclampsia?: Prospective cohort in Danish women",

abstract = "OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.DESIGN: Prospective cohort.SETTING: Denmark.POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.METHODS: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia.RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).CONCLUSIONS: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.",

keywords = "Adult, Denmark, Epidemiologic Methods, Exercise, Female, Humans, Journal Article, Leisure Activities, Pre-Eclampsia, Pregnancy, Pregnancy Trimester, First, Research Support, Non-U.S. Gov't, Young Adult",

author = "{\O}sterdal, {M L} and M Str{\o}m and Klemmensen, {A K} and Knudsen, {V K} and M Juhl and Halldorsson, {T I} and {Nybo Andersen}, A-M and P Magnus and Olsen, {S F}",

year = "2009",

month = jan,

doi = "10.1111/j.1471-0528.2008.02001.x",

language = "English",

volume = "116",

pages = "98--107",

journal = "BJOG : an international journal of obstetrics and gynaecology",

issn = "1470-0328",

publisher = "John Wiley and Sons Inc.",

number = "1",

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Østerdal, ML, Strøm, M, Klemmensen, AK, Knudsen, VK, Juhl, M, Halldorsson, TI, Nybo Andersen, A-M, Magnus, P & Olsen, SF 2009, 'Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women', BJOG : an international journal of obstetrics and gynaecology, bind 116, nr. 1, s. 98-107. https://doi.org/10.1111/j.1471-0528.2008.02001.x

TY - JOUR

T1 - Does leisure time physical activity in early pregnancy protect against pre-eclampsia?

T2 - Prospective cohort in Danish women

AU - Østerdal, M L

AU - Strøm, M

AU - Klemmensen, A K

AU - Knudsen, V K

AU - Juhl, M

AU - Halldorsson, T I

AU - Nybo Andersen, A-M

AU - Magnus, P

AU - Olsen, S F

PY - 2009/1

Y1 - 2009/1

N2 - OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.DESIGN: Prospective cohort.SETTING: Denmark.POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.METHODS: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia.RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).CONCLUSIONS: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

AB - OBJECTIVE: To examine the association between physical activity in early pregnancy and risk of pre-eclampsia.DESIGN: Prospective cohort.SETTING: Denmark.POPULATION: A total of 85,139 pregnant Danish women, recruited between 1996 and 2002.METHODS: The authors assessed leisure time physical activity in first trimester by a telephone interview and categorised women a priori into seven groups: 0 (reference), 1-44, 45-74, 75-149, 150-269, 270-419 and 420+ minutes/week. Pre-eclampsia diagnoses were extracted from the Danish National Patient Registry. A number of potential confounders were adjusted for by logistic regression.MAIN OUTCOME MEASURES: Pre-eclampsia and severe pre-eclampsia.RESULTS: The two highest physical activity levels were associated with increased risk of severe pre-eclampsia compared with the nonexercising group, with adjusted odds ratios of 1.65 (95% CI: 1.11-2.43) and 1.78 (95% CI: 1.07-2.95), whereas more moderate levels of physical activity (1-270 minutes/week) had no statistically significant association with risk of pre-eclampsia (total n = 85,139).CONCLUSIONS: We were unable to document a protective effect of leisure time physical activity against pre-eclampsia. Our data even suggest that leisure time physical activity exceeding 270 minutes/week in first trimester may increase risk of severe pre-eclampsia.

KW - Adult

KW - Denmark

KW - Epidemiologic Methods

KW - Exercise

KW - Female

KW - Humans

KW - Journal Article

KW - Leisure Activities

KW - Pre-Eclampsia

KW - Pregnancy

KW - Pregnancy Trimester, First

KW - Research Support, Non-U.S. Gov't

KW - Young Adult

U2 - 10.1111/j.1471-0528.2008.02001.x

DO - 10.1111/j.1471-0528.2008.02001.x

M3 - Journal article

C2 - 19055653

SN - 1470-0328

VL - 116

SP - 98

EP - 107

JO - BJOG : an international journal of obstetrics and gynaecology

JF - BJOG : an international journal of obstetrics and gynaecology

IS - 1

ER -

Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women

Abstract

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