Methods: 255 breast cancer survivors with sleep disturbances were randomized to iCBT-I or waitlist control and completed online measures of insomnia severity (ISI), global sleep quality (PSQI), and fatigue (FACIT-F) at baseline (T1), postintervention (T2), and follow-up (T3) together with online sleep diaries over two-week periods at T1 and T2. Indirect effects of changes in sleep outcomes on changes in fatigue were explored with regression-based mediation analyses.
Results: Statistically significant indirect effects on T1-T2 changes in fatigue were found for T1-T2 changes in ISI (-0.48; 95%CI: -0.70 – -0.29), PSQI (-0.33; 95%CI: -0.48 – -0.21), and diary-based subjective sleep quality (SQ) (-0.27; 95%CI: -0.45 – -0.11). T1-T2 changes ISI scores also mediated T2-T3 changes in fatigue (-0.29; 95%CI: -0.50 – -0.08). No indirect effects were found of improvements in the diary-based outcomes of sleep onset latency (SOL), wake after sleep onset (WASO), total sleep time (TST), early morning awakenings (EMA), time in bed (TIB), or sleep efficiency (SE).
Conclusions: In the sample of breast cancer survivors, the effects of iCBT-I on fatigue appeared to be driven by changes in the subjective sleep outcomes of insomnia severity and sleep quality, whereas changes in sleep diary-based outcomes, e.g., SOL, WASO, and TST, appeared unrelated to improvements in fatigue.
|Publikationsdato||31 okt. 2018|
|Status||Udgivet - 31 okt. 2018|
|Begivenhed||The 20th International Psycho-Oncology Society World Congress - Hong Kong, Hong Kong, Kina|
Varighed: 31 okt. 2018 → 2 nov. 2018
|Konference||The 20th International Psycho-Oncology Society World Congress|
|Periode||31/10/18 → 02/11/18|
- Sundhed, ernæring og livskvalitet