Excitatory and inhibitory pathways modulate kainate excitotoxicity in hippocampal slice cultures

P Casaccia-Bonnefil, E Benedikz, R Rai, P J Bergold

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In organotypic hippocampal slice cultures, kainate (KA) specifically induces cell loss in the CA3 region while N-methyl-D-aspartate induces cell loss in the CA1 region. The sensitivity of slice cultures to KA toxicity appears only after 2 weeks in vitro which parallels the appearance of mossy fibers. KA toxicity is potentiated by co-application with the GABA-A antagonist, picrotoxin. These data suggest that the excitotoxicity of KA in slice cultures is modulated by both excitatory and inhibitory synapses.

TidsskriftNeuroscience Letters
Udgave nummer1-2
Sider (fra-til)5-8
Antal sider4
StatusUdgivet - 14 maj 1993
Udgivet eksterntJa