Glycan-mediated modification of the immune response

Caroline Benedicte Kjærulff Mathiesen; Anders Elm Pedersen; Hans H. Wandall

doi:10.4161/onci.23659

Glycan-mediated modification of the immune response

Caroline Benedicte Kjærulff Mathiesen
, Anders Elm Pedersen
, Hans H. Wandall

Københavns Universitet

Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

Abstract

Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

Originalsprog	Engelsk
Artikelnummer	e23659
Tidsskrift	Oncoimmunology
Vol/bind	2
Udgave nummer	4
Sider (fra-til)	e23659
ISSN	2162-4011
DOI	https://doi.org/10.4161/onci.23659
Status	Udgivet - apr. 2013
Udgivet eksternt	Ja

Emneord

Kliniske undersøgelsesmetoder, laboratorieteknologi og radiografi

Adgang til dokumentet

10.4161/onci.23659Licens: CC BY

Citationsformater

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title = "Glycan-mediated modification of the immune response",

abstract = "Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.",

keywords = "clinical assessment methods, lab technology and radiography, C-type lectins, GalNAc, carbohydrate receptors, dendritic cells, glycans, vaccines",

author = "Mathiesen, \{Caroline Benedicte Kj{\ae}rulff\} and Pedersen, \{Anders Elm\} and Wandall, \{Hans H.\}",

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AU - Mathiesen, Caroline Benedicte Kjærulff

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N2 - Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

AB - Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

KW - clinical assessment methods, lab technology and radiography

KW - C-type lectins

KW - GalNAc

KW - carbohydrate receptors

KW - dendritic cells

KW - glycans

KW - vaccines

U2 - 10.4161/onci.23659

DO - 10.4161/onci.23659

M3 - Journal article

SN - 2162-4011

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JO - Oncoimmunology

JF - Oncoimmunology

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M1 - e23659

ER -

Glycan-mediated modification of the immune response

Abstract

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