Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

A.H. Chakera; B.S. Nielsen; J. Madsen; J. Romer; P.E.G. Kristjansen; Inge Buch; T Binderup; C. Ingvar; Amarnadh Nalla; A. Kjaer; Birger Hesse

Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model

A.H. Chakera, B.S. Nielsen, J. Madsen, J. Romer, P.E.G. Kristjansen, Inge Buch, T Binderup, C. Ingvar, Amarnadh Nalla, A. Kjaer, Birger Hesse

Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

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Abstract

Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune- deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

Originalsprog	Engelsk
Artikelnummer	828151
Tidsskrift	International Journal of Molecular Imaging
Vol/bind	2011
Antal sider	7
ISSN	2090-1712
Status	Udgivet - 2011

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Immunolymphoscintigraphy for Metastatic Sentinel Nodes : Test of a ModelForlagets udgivne version, 3,16 MB

Citationsformater

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title = "Immunolymphoscintigraphy for Metastatic Sentinel Nodes: Test of a Model",

abstract = "Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune- deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.",

author = "A.H. Chakera and B.S. Nielsen and J. Madsen and J. Romer and P.E.G. Kristjansen and Inge Buch and T Binderup and C. Ingvar and Amarnadh Nalla and A. Kjaer and Birger Hesse",

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TY - JOUR

T1 - Immunolymphoscintigraphy for Metastatic Sentinel Nodes

T2 - Test of a Model

AU - Chakera, A.H.

AU - Nielsen, B.S.

AU - Madsen, J.

AU - Romer, J.

AU - Kristjansen, P.E.G.

AU - Buch, Inge

AU - Binderup, T

AU - Ingvar, C.

AU - Nalla, Amarnadh

AU - Kjaer, A.

AU - Hesse, Birger

PY - 2011

Y1 - 2011

N2 - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune- deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

AB - Aim. To develop a method and obtain proof-of-principle for immunolymphoscintigraphy for identification of metastatic sentinel nodes. Methods. We selected one of four tumour-specific antibodies against human breast cancer and investigated (1), in immune- deficient (nude) mice with xenograft human breast cancer expressing the antigen if specific binding of the intratumorally injected, radioactively labelled, monoclonal antibody could be scintigraphically visualized, and (2) transportation to and retention in regional lymph nodes of the radioactively labelled antibody after subcutaneous injection in healthy rabbits. Results and Conclusion. Our paper suggests the theoretical possibility of a model of dual isotope immuno-lymphoscintigraphy for noninvasive, preoperative, malignant sentinel node imaging.

M3 - Journal article

SN - 2090-1712

VL - 2011

JO - International Journal of Molecular Imaging

JF - International Journal of Molecular Imaging

M1 - 828151

ER -