Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg; Micael Andersson; Anders Lundquist; William F C Baaré; David Bartrés-Faz; Lars Bertram; Carl-Johan Boraxbekk; Andreas M Brandmaier; Naiara Demnitz; Christian A Drevon; Sandra Duezel; Klaus P Ebmeier; Paolo Ghisletta; Richard Henson; Daria E A Jensen; Rogier A Kievit; Ethan Knights; Simone Kühn; Ulman Lindenberger; Anna Plachti; Sara Pudas; James M Roe; Kathrine Skak Madsen; Cristina Solé-Padullés; Yasmine Sommerer; Sana Suri; Enikő Zsoldos; Anders M Fjell; Kristine B Walhovd

doi:10.1093/cercor/bhac400

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

Lars Nyberg, Micael Andersson, Anders Lundquist, William F C Baaré, David Bartrés-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M Brandmaier, Naiara Demnitz, Christian A Drevon, Sandra Duezel, Klaus P Ebmeier, Paolo Ghisletta, Richard Henson, Daria E A Jensen, Rogier A Kievit, Ethan Knights, Simone Kühn, Ulman Lindenberger, Anna PlachtiSara Pudas, James M Roe, Kathrine Skak Madsen, Cristina Solé-Padullés, Yasmine Sommerer, Sana Suri, Enikő Zsoldos, Anders M Fjell, Kristine B Walhovd

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Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

Abstract

It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

Originalsprog	Engelsk
Tidsskrift	Cerebral Cortex
Vol/bind	33
Udgave nummer	9
Sider (fra-til)	5075-5081
Antal sider	7
ISSN	1047-3211
DOI	https://doi.org/10.1093/cercor/bhac400
Status	Udgivet - 1 maj 2023

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10.1093/cercor/bhac400

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Nyberg, L., Andersson, M., Lundquist, A., Baaré, W. F. C., Bartrés-Faz, D., Bertram, L., Boraxbekk, C.-J., Brandmaier, A. M., Demnitz, N., Drevon, C. A., Duezel, S., Ebmeier, K. P., Ghisletta, P., Henson, R., Jensen, D. E. A., Kievit, R. A., Knights, E., Kühn, S., Lindenberger, U., ... Walhovd, K. B. (2023). Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates. Cerebral Cortex, 33(9), 5075-5081. https://doi.org/10.1093/cercor/bhac400

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title = "Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates",

abstract = "It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.",

author = "Lars Nyberg and Micael Andersson and Anders Lundquist and Baar{\'e}, {William F C} and David Bartr{\'e}s-Faz and Lars Bertram and Carl-Johan Boraxbekk and Brandmaier, {Andreas M} and Naiara Demnitz and Drevon, {Christian A} and Sandra Duezel and Ebmeier, {Klaus P} and Paolo Ghisletta and Richard Henson and Jensen, {Daria E A} and Kievit, {Rogier A} and Ethan Knights and Simone K{\"u}hn and Ulman Lindenberger and Anna Plachti and Sara Pudas and Roe, {James M} and Madsen, {Kathrine Skak} and Cristina Sol{\'e}-Padull{\'e}s and Yasmine Sommerer and Sana Suri and Enik{\H o} Zsoldos and Fjell, {Anders M} and Walhovd, {Kristine B}",

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year = "2023",

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doi = "10.1093/cercor/bhac400",

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Nyberg, L, Andersson, M, Lundquist, A, Baaré, WFC, Bartrés-Faz, D, Bertram, L, Boraxbekk, C-J, Brandmaier, AM, Demnitz, N, Drevon, CA, Duezel, S, Ebmeier, KP, Ghisletta, P, Henson, R, Jensen, DEA, Kievit, RA, Knights, E, Kühn, S, Lindenberger, U, Plachti, A, Pudas, S, Roe, JM, Madsen, KS, Solé-Padullés, C, Sommerer, Y, Suri, S, Zsoldos, E, Fjell, AM & Walhovd, KB 2023, 'Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates', Cerebral Cortex, bind 33, nr. 9, s. 5075-5081. https://doi.org/10.1093/cercor/bhac400

TY - JOUR

T1 - Individual differences in brain aging

T2 - heterogeneity in cortico-hippocampal but not caudate atrophy rates

AU - Nyberg, Lars

AU - Andersson, Micael

AU - Lundquist, Anders

AU - Baaré, William F C

AU - Bartrés-Faz, David

AU - Bertram, Lars

AU - Boraxbekk, Carl-Johan

AU - Brandmaier, Andreas M

AU - Demnitz, Naiara

AU - Drevon, Christian A

AU - Duezel, Sandra

AU - Ebmeier, Klaus P

AU - Ghisletta, Paolo

AU - Henson, Richard

AU - Jensen, Daria E A

AU - Kievit, Rogier A

AU - Knights, Ethan

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Plachti, Anna

AU - Pudas, Sara

AU - Roe, James M

AU - Madsen, Kathrine Skak

AU - Solé-Padullés, Cristina

AU - Sommerer, Yasmine

AU - Suri, Sana

AU - Zsoldos, Enikő

AU - Fjell, Anders M

AU - Walhovd, Kristine B

PY - 2023/5/1

Y1 - 2023/5/1

N2 - It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

AB - It is well documented that some brain regions, such as association cortices, caudate, and hippocampus, are particularly prone to age-related atrophy, but it has been hypothesized that there are individual differences in atrophy profiles. Here, we document heterogeneity in regional-atrophy patterns using latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. The higher-atrophy group had the most marked atrophy in hippocampus and also lower episodic memory, and their normal caudate atrophy rate was accompanied by larger baseline volumes. Our findings support and refine models of heterogeneity in brain aging and suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.

UR - http://www.scopus.com/inward/record.url?scp=85159256770&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhac400

DO - 10.1093/cercor/bhac400

M3 - Journal article

C2 - 36197324

SN - 1047-3211

VL - 33

SP - 5075

EP - 5081

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 9

ER -

Individual differences in brain aging: heterogeneity in cortico-hippocampal but not caudate atrophy rates

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