Nucleotides, nucleosides, and nucleobases

Kaj Frank Jensen, Gert Dandanell, Bjarne Hove-Jensen, Martin Willemoës

    Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

    Abstract

    We review literature on the metabolism of ribo- and deoxyribonucleotides, nucleosides, and nucleobases in Escherichia coli and Salmonella,including biosynthesis, degradation, interconversion, and transport. Emphasis is placed on enzymology and regulation of the pathways, at both the level of gene expression and the control of enzyme activity. The paper begins with an overview of the reactions that form and break the N-glycosyl bond, which binds the nucleobase to the ribosyl moiety in nucleotides and nucleosides, and the enzymes involved in the interconversion of the different phosphorylated states of the nucleotides. Next, the de novo pathways for purine and pyrimidine nucleotide biosynthesis are discussed in detail.Finally, the conversion of nucleosides and nucleobases to nucleotides, i.e.,the salvage reactions, are described. The formation of deoxyribonucleotides is discussed, with emphasis on ribonucleotidereductase and pathways involved in fomation of dUMP. At the end, we discuss transport systems for nucleosides and nucleobases and also pathways for breakdown of the nucleobases.
    OriginalsprogEngelsk
    TidsskriftEcoSal Plus
    Vol/bind3
    Udgave nummer1
    ISSN2324-6200
    DOI
    StatusUdgivet - 2008

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