Point of care testing of fecal calprotectin as a substitute for routine laboratory analysis

Bidragets oversatte titel: Point of care testing of fecal calprotectin as a substitute for routine laboratory analysis

Julie Hejl, Klaus Theede, Brian Møllgren, Kirsten Vikkelsø Madsen, Ashraf Heidari, Anna á Steig, Mogens Fenger

    Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

    Abstract

    Objectives

    Fecal calprotectin (FC) is widely used to monitor the activity of inflammatory bowel disease (IBD) and to tailor medical treatment to disease activity. Laboratory testing of fecal samples may have a turnaround time of 1–2 weeks, whereas FC home testing allows results within hours and thus enables a rapid response to clinical deterioration.

    Design and methods

    Fifty-five stool samples were analyzed by the IBDoc® Calprotectin Home Testing kit and the BÜHLMANN fCAL® turbo assay on a Roche Cobas 6000 c501. The correlation between the assays was assessed using Spearman's Rho correlation coefficient and the intermediate imprecision of both assays was calculated.

    Results

    We found a strong correlation coefficient of 0.887 between FC measured on IBDoc® and the laboratory assay BÜHLMANN fCAL® turbo. The coefficients of variation (CVs) at three different FC levels were in the range 2.3–5.5% (BÜHLMANN fCAL® turbo) and in the range of 4.8–26.6% (IBDoc®).

    Conclusions

    This study suggests that IBDoc® is a suitable alternative for the assessment of disease activity in IBD patients.
    Bidragets oversatte titelPoint of care testing of fecal calprotectin as a substitute for routine laboratory analysis
    OriginalsprogEngelsk
    TidsskriftPractical Laboratory Medicine
    Vol/bind10
    Sider (fra-til)10-14
    Antal sider5
    ISSN2352-5517
    DOI
    StatusUdgivet - mar. 2018

    Emneord

    • Kliniske undersøgelsesmetoder, laboratorieteknologi og radiografi
    • Sygdom, sundhedsvidenskab og sygepleje

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