Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure

Sara Krøis Damsted, Kathrine Skak Madsen, Martin Vestergaard, Alfred Peter Born, Olaf B Paulson, Hartwig Roman Siebner, Peter Vilhelm Uldall, William F C Baaré

    Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

    Abstract

    Glucocorticoids are widely used in the treatment of several pediatric diseases with undisputed disease-related benefits. Perinatal exposure to high levels of glucocorticoids can have long-term adverse cerebral effects. In adults, glucocorticoid treatment has been associated with smaller volumes of subcortical grey matter structures. Recently, we observed smaller total brain volumes in children and adolescents treated with glucocorticoid during childhood compared to healthy controls. The possible long-term effects of glucocorticoid treatment during childhood on subcortical brain volume and microstructure remain unknown.
    OriginalsprogEngelsk
    Artikelnummer101825
    TidsskriftNeuroImage
    Vol/bind23
    Sider (fra-til)1-11
    Antal sider11
    ISSN1053-8119
    DOI
    StatusUdgivet - 2019

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