Solid-phase synthesis of polyfunctional polylysine dendrons using aldehyde linkers

Daniel K. Svenssen, Sahar Mirsharghi, Ulrik Boas

Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

Abstract

A straightforward method for the solid-phase synthesis of C-terminally modified polylysine dendrons has been developed by applying bisalkoxybenzaldehyde and trisalkoxybenzaldehyde linkers. The method has been used for the synthesis of polylysine dendrons with a variety of C-terminal 'tail groups' such as alkyl, propargyl, and dansyl to give dendrons in high crude purity. Furthermore, the method was successful for the synthesis of dendrons with multiple N-terminal pentapeptide groups together with C-terminal alkyl and propargyl tail groups. Finally, the method was shown to be well-suited for automated synthesis.
OriginalsprogEngelsk
TidsskriftTetrahedron Letters
Vol/bind55
Udgave nummer29
Sider (fra-til)3942-3945
Antal sider4
ISSN0040-4039
DOI
StatusUdgivet - 16 jul. 2014
Udgivet eksterntJa

Emneord

  • Backbone amide linker
  • Polyfunctional
  • Polylysine dendron
  • Solid-phase synthesis

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