The development of diabetes among Danish cystic fibrosis patients over the last two decades

Karin B. Knudsen, Elisabeth R. Mathiesen, Vibeke Eriksen, Marianne Skov, Kim G. Nielsen, Jesper Johannesen, Tacjana Pressler

Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

Abstract

OBJECTIVE: Cystic fibrosis (CF)-related diabetes (CFRD) is correlated with age and has been associated with a decline in body mass index (BMI), pulmonary function, and survival. Over the last two decades, the focus has been on the early diagnosis and treatment of diabetes; therefore, in this study, we evaluated the status of the current clinical condition and survival in our CF population. In addition, we also aimed to investigate the incidence of diabetes among adolescence over time and to identify characteristics associated with early diabetes onset.\n\nMETHODS: A retrospective chart review of a birth cohort consisting of 161 CF patients born between 1975 and 1994 and followed until 2011.\n\nRESULTS: Over two decades, the incidence of CFRD among 11- to 16-year-old children remained unchanged at 12-14%, while the proportion of children with chronic pulmonary infection at age 10 declined from 31 to 8% (p <0.001). Severe CF-mutation, i.e., group I and II mutations, were associated with diabetes (p = 0.003). Female gender was borderline associated with diabetes among adolescents (p = 0.06). No significant worsening in pulmonary function, BMI or survival was identified when comparing CFRD patients to CF patients without CFRD.\n\nCONCLUSIONS: The incidence of diabetes among adolescence with CF has not changed over the last two decades. Severe CF mutations are a risk factor for CFRD, and female gender is borderline associated with CFRD among adolescents. Pulmonary function, BMI and survival were comparable regardless of the onset of CFRD.
OriginalsprogDansk
TidsskriftPediatric Diabetes
Sider (fra-til)219-226
Antal sider8
ISSN1399-543X
DOI
StatusUdgivet - 1 maj 2015
Udgivet eksterntJa

Emneord

  • Clinical outcomes
  • Cystic fibrosis
  • Diabetes mellitus
  • Epidemiology

Citationsformater

Knudsen, K. B., Mathiesen, E. R., Eriksen, V., Skov, M., Nielsen, K. G., Johannesen, J., & Pressler, T. (2015). The development of diabetes among Danish cystic fibrosis patients over the last two decades. Pediatric Diabetes, 219-226. https://doi.org/10.1111/pedi.12143