Triplex-forming ability of modified oligonucleotides.

Torben René Højland, Bolle Ravindra Babu, Torsten Bryld, Jesper Wengel

Publikation: Bidrag til tidsskriftTidsskriftsartikelForskningpeer review

Abstract

We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4'-C-hydroxymethyl, LNA, 2'-amino-LNA and N2'-functionalized 2'-amino-LNA. Triplexes containing monomers of N2'-glycyl-functionalized 2'-amino-LNA are particularly stable.
OriginalsprogUdefineret/Ukendt
TidsskriftNucleosides, Nucleotides and Nucleic Acids
ISSN1525-7770
DOI
StatusUdgivet - 1 jan. 2007
Udgivet eksterntJa

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