Triplex-forming ability of modified oligonucleotides.

Torben René Højland; Bolle Ravindra Babu; Torsten Bryld; Jesper Wengel

doi:https://doi.org/10.1080/15257770701539047

Triplex-forming ability of modified oligonucleotides.

Torben René Højland, Bolle Ravindra Babu, Torsten Bryld, Jesper Wengel

Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

Abstract

We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4'-C-hydroxymethyl, LNA, 2'-amino-LNA and N2'-functionalized 2'-amino-LNA. Triplexes containing monomers of N2'-glycyl-functionalized 2'-amino-LNA are particularly stable.

Originalsprog	Udefineret/Ukendt
Tidsskrift	Nucleosides, Nucleotides and Nucleic Acids
ISSN	1525-7770
DOI	https://doi.org/10.1080/15257770701539047
Status	Udgivet - 1 jan. 2007
Udgivet eksternt	Ja

Adgang til dokumentet

https://doi.org/10.1080/15257770701539047

Citationsformater

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AU - Højland, Torben René

AU - Babu, Bolle Ravindra

AU - Bryld, Torsten

AU - Wengel, Jesper

PY - 2007/1/1

Y1 - 2007/1/1

N2 - We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4'-C-hydroxymethyl, LNA, 2'-amino-LNA and N2'-functionalized 2'-amino-LNA. Triplexes containing monomers of N2'-glycyl-functionalized 2'-amino-LNA are particularly stable.

AB - We present our studies on the ability of several different nucleotide analogs as triplex-forming oligonucleotides. The modifications tested include 4'-C-hydroxymethyl, LNA, 2'-amino-LNA and N2'-functionalized 2'-amino-LNA. Triplexes containing monomers of N2'-glycyl-functionalized 2'-amino-LNA are particularly stable.

UR - https://portal.findresearcher.sdu.dk/en/publications/8e1fda20-e0ca-11dc-a57f-000ea68e967b

U2 - https://doi.org/10.1080/15257770701539047

DO - https://doi.org/10.1080/15257770701539047

M3 - Tidsskriftsartikel

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JO - Nucleosides, Nucleotides and Nucleic Acids

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