Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

Bjørn A Nexø; Sara B Jensen; Kari K Nissen; Bettina Hansen; Magdalena J Laska

doi:10.1186/s12883-016-0580-9

Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

Bjørn A Nexø, Sara B Jensen, Kari K Nissen, Bettina Hansen, Magdalena J Laska

Aarhus Universitet

Publikation: Bidrag til tidsskrift › Tidsskriftsartikel › Forskning › peer review

Abstract

BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).

RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.

CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

Originalsprog	Engelsk
Tidsskrift	BMC Neurology
Vol/bind	16
Sider (fra-til)	57
ISSN	1471-2377
DOI	https://doi.org/10.1186/s12883-016-0580-9
Status	Udgivet - 2016
Udgivet eksternt	Ja

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10.1186/s12883-016-0580-9

Citationsformater

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title = "Two endogenous retroviral loci appear to contribute to Multiple Sclerosis",

abstract = "BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.",

keywords = "journal Article, research Support, Non-U.S. Gov't, review",

author = "Nex{\o}, {Bj{\o}rn A} and Jensen, {Sara B} and Nissen, {Kari K} and Bettina Hansen and Laska, {Magdalena J}",

year = "2016",

doi = "10.1186/s12883-016-0580-9",

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volume = "16",

pages = "57",

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TY - JOUR

T1 - Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

AU - Nexø, Bjørn A

AU - Jensen, Sara B

AU - Nissen, Kari K

AU - Hansen, Bettina

AU - Laska, Magdalena J

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

AB - BACKGROUND: Two endogenous retroviral loci seem to be involved in the human disease Multiple sclerosis (MS).RESULTS: The two retroviral loci synergize in and contribute to MS (shown by ANOVA). Synergy probably means recombination or complementation of the activated viruses. Similar observations may be true for Type 1 Diabetes and Rheumatoid arthritis. In MS the genes also synergize with the immune system; this could well be a common phenomenon.CONCLUSION: We formulate various theories about the role of the viruses. Also, the concept is developing that some forms of autoimmunity should be treatable with antiretrovirals. In the case of MS, this idea is gradually gaining weight.

KW - journal Article

KW - research Support, Non-U.S. Gov't

KW - review

U2 - 10.1186/s12883-016-0580-9

DO - 10.1186/s12883-016-0580-9

M3 - Journal article

C2 - 27130045

SN - 1471-2377

VL - 16

SP - 57

JO - BMC Neurology

JF - BMC Neurology

ER -

Two endogenous retroviral loci appear to contribute to Multiple Sclerosis

Abstract

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