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A Generic Framework for Systematic Design of Process Monitoring and Control System for Crystallization Processes

  • Noor Asma Fazli Bin Abdul Samad
  • , Kresten Troelstrup Meisler
  • , Gürkan Sin
  • , Krist Gernaey
  • , Rafiqul Gani
  • Technical University of Denmark

Research output: Chapter in Book/Report/Conference proceedingConference contribution to proceedingpeer-review

Abstract

A generic framework for systematic design of a process monitoring and control system for crystallization processes has been developed in order to obtain the desired end-product properties notably the crystal size distribution (CSD). The design framework contains a generic crystallizer modelling tool-box, a tool for design of operational policies as well as a tool for design of process monitoring and control systems. Through this framework, it is possible for a wide range of crystallization processes to generate the necessary problem-system specific model, the necessary operational policy and a Process Analytical Technology (PAT) system design including implementation of monitoring tools and control strategies in order to produce a desired product with its corresponding target properties. Application of the framework is highlighted through a case study involving the system potassium dihydrogen phosphate (KDP), for which the targeted CSD is defined and achieved in one- and two-dimensional schemes.
Original languageEnglish
Title of host publication22nd European symposium on computer aided process engineering
EditorsIan David Lockhart, Michael Fairweather
PublisherElsevier
Publication date2012
ISBN (Print)9780444594310
Publication statusPublished - 2012
Externally publishedYes
SeriesComputer - Aided Chemical Engineering
Volume30

Keywords

  • Analytical CSD estimator
  • Crystallization
  • Design of process monitoring and control systems
  • Generic crystallization modelling
  • Response surface method

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