A prospective study of nutritional status in immunoglobulin light chain amyloidosis

PT Sattianayagam; T Lane; Z Fox; A Petrie; SD Gibbs; JH Pinney; Signe Stelling Risom; DM Rowczenio; AD Wechalekar; HJ Lachmann; JA Gilbertson; PN Hawkins; JD Gilmore

doi:10.3324/haematol.2012.070359

A prospective study of nutritional status in immunoglobulin light chain amyloidosis

PT Sattianayagam
, T Lane
, Z Fox
, A Petrie
, SD Gibbs
, JH Pinney
, Signe Stelling Risom
, DM Rowczenio
, AD Wechalekar
, HJ Lachmann
, JA Gilbertson
, PN Hawkins
, JD Gilmore

National Amyloidosis Centre, Centre for Amyloidosis & Acute Phase Proteins

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P<0.05). Quality of life was substantially poorer among those with higher PG-SGA scores (P<0.001). Furthermore, PG-SGA score was a powerful independent predictor of patient survival (P=0.02). Malnutrition is prevalent and is associated with poor quality of life and reduced survival among patients with systemic immunoglobulin light chain amyloidosis. The PG-SGA score would be an appropriate tool to evaluate whether nutritional intervention could improve patient outcomes.

Original language	English
Journal	Haematologica
Volume	98
Issue number	1
Pages (from-to)	136-140
Number of pages	5
ISSN	0390-6078
DOIs	https://doi.org/10.3324/haematol.2012.070359
Publication status	Published - 1 Jan 2013
Externally published	Yes

Keywords

nutrition

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10.3324/haematol.2012.070359

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title = "A prospective study of nutritional status in immunoglobulin light chain amyloidosis",

abstract = "Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-na{\"i}ve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66\%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P<0.05). Quality of life was substantially poorer among those with higher PG-SGA scores (P<0.001). Furthermore, PG-SGA score was a powerful independent predictor of patient survival (P=0.02). Malnutrition is prevalent and is associated with poor quality of life and reduced survival among patients with systemic immunoglobulin light chain amyloidosis. The PG-SGA score would be an appropriate tool to evaluate whether nutritional intervention could improve patient outcomes.",

keywords = "nutrition",

author = "PT Sattianayagam and T Lane and Z Fox and A Petrie and SD Gibbs and JH Pinney and Risom, \{Signe Stelling\} and DM Rowczenio and AD Wechalekar and HJ Lachmann and JA Gilbertson and PN Hawkins and JD Gilmore",

note = "Funding Information: This work was supported by a grant from the National Institutes of Health (HL094505) to BZ.",

year = "2013",

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doi = "10.3324/haematol.2012.070359",

language = "English",

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T1 - A prospective study of nutritional status in immunoglobulin light chain amyloidosis

AU - Sattianayagam, PT

AU - Lane, T

AU - Fox, Z

AU - Petrie, A

AU - Gibbs, SD

AU - Pinney, JH

AU - Risom, Signe Stelling

AU - Rowczenio, DM

AU - Wechalekar, AD

AU - Lachmann, HJ

AU - Gilbertson, JA

AU - Hawkins, PN

AU - Gilmore, JD

N1 - Funding Information: This work was supported by a grant from the National Institutes of Health (HL094505) to BZ.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P<0.05). Quality of life was substantially poorer among those with higher PG-SGA scores (P<0.001). Furthermore, PG-SGA score was a powerful independent predictor of patient survival (P=0.02). Malnutrition is prevalent and is associated with poor quality of life and reduced survival among patients with systemic immunoglobulin light chain amyloidosis. The PG-SGA score would be an appropriate tool to evaluate whether nutritional intervention could improve patient outcomes.

AB - Weight loss is common in systemic immunoglobulin light chain amyloidosis but there are limited data on the impact of nutritional status on outcome. Using the Patient-Generated Subjective Global Assessment (PG-SGA) score, we prospectively examined nutritional status in 110 consecutive newly-diagnosed, treatment-naïve patients with immunoglobulin light chain amyloidosis attending the UK National Amyloidosis Centre. At study entry, 72 of 110 (66%) patients had a PG-SGA score of 4 or over, indicating malnutrition requiring specialist nutritional intervention. Number of amyloidotic organs, elevated alkaline phosphatase, presence of autonomic neuropathy and advanced Mayo disease stage were independently associated with poor nutritional status (P<0.05). Quality of life was substantially poorer among those with higher PG-SGA scores (P<0.001). Furthermore, PG-SGA score was a powerful independent predictor of patient survival (P=0.02). Malnutrition is prevalent and is associated with poor quality of life and reduced survival among patients with systemic immunoglobulin light chain amyloidosis. The PG-SGA score would be an appropriate tool to evaluate whether nutritional intervention could improve patient outcomes.

KW - nutrition

UR - https://www.scopus.com/pages/publications/84872069528

U2 - 10.3324/haematol.2012.070359

DO - 10.3324/haematol.2012.070359

M3 - Journal article

SN - 0390-6078

VL - 98

SP - 136

EP - 140

JO - Haematologica

JF - Haematologica

IS - 1

ER -

A prospective study of nutritional status in immunoglobulin light chain amyloidosis

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Keywords

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