A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation

Ronnie Folkesson, Katarzyna Malkiewicz, Ewa Kloskowska, Tatjana Nilsson, Elena Popova, Nenad Bogdanovic, Ursula Ganten, Detlev Ganten, Michael Bader, Bengt Winblad, Eirikur Benedikz

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular Abeta staining. The Abeta is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PS1 transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice.

Original languageEnglish
JournalBiochemical and Biophysical Research Communications
Volume358
Issue number3
Pages (from-to)777-82
Number of pages6
ISSN0006-291X
DOIs
Publication statusPublished - 6 Jul 2007
Externally publishedYes

Keywords

  • Alzheimer Disease
  • Amyloid
  • Animals
  • Animals, Genetically Modified
  • Brain
  • Cerebellum
  • Cerebral Cortex
  • Genetic Techniques
  • Hippocampus
  • Humans
  • Journal Article
  • Mutation
  • Presenilin-1
  • Rats
  • Research Support, Non-U.S. Gov't
  • Sweden
  • tau Proteins

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