Alzheimer transgenic models

R Folkesson, B Winblad, E Benedikz

Research output: Contribution to journalJournal articleResearchpeer-review


Purpose of review A number of Alzheimer transgenic mouse models have been generated using a variety of different constructs containing the amyloid precursor protein. Some of the models develop features of Alzheimer's disease, including amyloid pathology, cholinergic deficits and cognitive impairment. Recent publications have demonstrated the benefits of using transgenic animals as models of Alzheimer's disease. transgenes relevant to Alzheimer's disease have enhanced our understanding of the underlying pathogenic mechanisms. In the past year the Alzheimer transgenic models have increasingly been used in the development of anti-Alzheimer drugs. complete models of Alzheimer's disease, they are useful for studies on pathogenic mechanisms and the evaluation of new anti-amyloid treatment strategies. [References: 48]
Original languageEnglish
JournalCurrent Opinion in Psychiatry
Issue number4
Pages (from-to)433-439
Number of pages7
Publication statusPublished - 2002
Externally publishedYes

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