DNA methylation status correlates with adult β-cell regeneration capacity

Ishant Khurana; Keith Al-Hasani; Scott Maxwell; Harikrishnan K N; Jun Okabe; Mark E Cooper; Patrick Collombat; Assam El-Osta

doi:10.1038/s41536-021-00119-1

DNA methylation status correlates with adult β-cell regeneration capacity

Ishant Khurana
, Keith Al-Hasani
, Scott Maxwell
, Harikrishnan K N
, Jun Okabe
, Mark E Cooper
, Patrick Collombat
, Assam El-Osta

Bioanalytikeruddannelsen

Monash University, Australia
Université Côte d’Azur, GREDEG, Valbonne, France
Steno Diabetes Center Copenhagen
University of Melbourne

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

Original language	English
Article number	7
Journal	Regenerative Medicine
Volume	6
Issue number	1
Pages (from-to)	7
ISSN	1746-0751
DOIs	https://doi.org/10.1038/s41536-021-00119-1
Publication status	Published - Dec 2021

Keywords

biomedical laboratory analysis

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10.1038/s41536-021-00119-1

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title = "DNA methylation status correlates with adult β-cell regeneration capacity",

abstract = "The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.",

keywords = "biomedical laboratory analysis",

author = "Ishant Khurana and Keith Al-Hasani and Scott Maxwell and \{K N\}, Harikrishnan and Jun Okabe and Cooper, \{Mark E\} and Patrick Collombat and Assam El-Osta",

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T1 - DNA methylation status correlates with adult β-cell regeneration capacity

AU - Khurana, Ishant

AU - Al-Hasani, Keith

AU - Maxwell, Scott

AU - K N, Harikrishnan

AU - Okabe, Jun

AU - Cooper, Mark E

AU - Collombat, Patrick

AU - El-Osta, Assam

PY - 2021/12

Y1 - 2021/12

N2 - The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

AB - The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.

KW - biomedical laboratory analysis

UR - https://www.scopus.com/pages/publications/85100954626

U2 - 10.1038/s41536-021-00119-1

DO - 10.1038/s41536-021-00119-1

M3 - Journal article

C2 - 33580013

SN - 1746-0751

VL - 6

SP - 7

JO - Regenerative Medicine

JF - Regenerative Medicine

IS - 1

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ER -

DNA methylation status correlates with adult β-cell regeneration capacity

Abstract

Keywords

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