Dynamic contrast-enhanced CT in patients with pancreatic cancer

Carsten Ammitzbøl Lauridsen; Rie Østbjerg Eriksen; Louise Søborg Strauch; Michael Bachmann Nielsen; Michael Sandgaard; Thomas Skaarup Kristensen

doi:10.3390/diagnostics6030034

Dynamic contrast-enhanced CT in patients with pancreatic cancer

Carsten Ammitzbøl Lauridsen
, Rie Østbjerg Eriksen
, Louise Søborg Strauch
, Michael Bachmann Nielsen
, Michael Sandgaard
, Thomas Skaarup Kristensen

Copenhagen University Hospital

Research output: Contribution to journal › Review article › peer-review

Abstract

The aim of this systematic review is to provide an overview of the use of Dynamic Contrast-enhanced Computed Tomography (DCE-CT) in patients with pancreatic cancer. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases to identify all relevant publications. The QUADAS-2 tool was implemented to assess the risk of bias and applicability concerns of each included study. The initial literature search yielded 483 publications. Thirteen articles were included. Articles were categorized into three groups: nine articles concerning primary diagnosis or staging, one article about tumor response to treatment, and three articles regarding scan techniques. In exocrine pancreatic tumors, measurements of blood flow in eight studies and blood volume in seven studies were significantly lower in tumor tissue, compared with measurements in pancreatic tissue outside of tumor, or normal pancreatic tissue in control groups of healthy volunteers. The studies were heterogeneous in the number of patients enrolled and scan protocols. Perfusion parameters measured and analyzed by DCE-CT might be useful in the investigation of characteristic vascular patterns of exocrine pancreatic tumors. Further clinical studies are desired for investigating the potential of DCE-CT in pancreatic tumors.

Original language	English
Article number	34
Journal	Diagnostics
Volume	6
Issue number	3
Pages (from-to)	34
Number of pages	12
ISSN	2075-4418
DOIs	https://doi.org/10.3390/diagnostics6030034
Publication status	Published - 6 Sept 2016

Keywords

disease, health science and nursing
DCE-CT
diagnostics
pancreatic cancer
scan techniques
treatment response

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title = "Dynamic contrast-enhanced CT in patients with pancreatic cancer",

abstract = "The aim of this systematic review is to provide an overview of the use of Dynamic Contrast-enhanced Computed Tomography (DCE-CT) in patients with pancreatic cancer. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases to identify all relevant publications. The QUADAS-2 tool was implemented to assess the risk of bias and applicability concerns of each included study. The initial literature search yielded 483 publications. Thirteen articles were included. Articles were categorized into three groups: nine articles concerning primary diagnosis or staging, one article about tumor response to treatment, and three articles regarding scan techniques. In exocrine pancreatic tumors, measurements of blood flow in eight studies and blood volume in seven studies were significantly lower in tumor tissue, compared with measurements in pancreatic tissue outside of tumor, or normal pancreatic tissue in control groups of healthy volunteers. The studies were heterogeneous in the number of patients enrolled and scan protocols. Perfusion parameters measured and analyzed by DCE-CT might be useful in the investigation of characteristic vascular patterns of exocrine pancreatic tumors. Further clinical studies are desired for investigating the potential of DCE-CT in pancreatic tumors.",

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author = "Lauridsen, \{Carsten Ammitzb{\o}l\} and Eriksen, \{Rie {\O}stbjerg\} and Strauch, \{Louise S{\o}borg\} and Nielsen, \{Michael Bachmann\} and Michael Sandgaard and Kristensen, \{Thomas Skaarup\}",

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doi = "10.3390/diagnostics6030034",

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AU - Lauridsen, Carsten Ammitzbøl

AU - Eriksen, Rie Østbjerg

AU - Strauch, Louise Søborg

AU - Nielsen, Michael Bachmann

AU - Sandgaard, Michael

AU - Kristensen, Thomas Skaarup

PY - 2016/9/6

Y1 - 2016/9/6

N2 - The aim of this systematic review is to provide an overview of the use of Dynamic Contrast-enhanced Computed Tomography (DCE-CT) in patients with pancreatic cancer. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases to identify all relevant publications. The QUADAS-2 tool was implemented to assess the risk of bias and applicability concerns of each included study. The initial literature search yielded 483 publications. Thirteen articles were included. Articles were categorized into three groups: nine articles concerning primary diagnosis or staging, one article about tumor response to treatment, and three articles regarding scan techniques. In exocrine pancreatic tumors, measurements of blood flow in eight studies and blood volume in seven studies were significantly lower in tumor tissue, compared with measurements in pancreatic tissue outside of tumor, or normal pancreatic tissue in control groups of healthy volunteers. The studies were heterogeneous in the number of patients enrolled and scan protocols. Perfusion parameters measured and analyzed by DCE-CT might be useful in the investigation of characteristic vascular patterns of exocrine pancreatic tumors. Further clinical studies are desired for investigating the potential of DCE-CT in pancreatic tumors.

AB - The aim of this systematic review is to provide an overview of the use of Dynamic Contrast-enhanced Computed Tomography (DCE-CT) in patients with pancreatic cancer. This study was composed according to the PRISMA guidelines 2009. The literature search was conducted in PubMed, Cochrane Library, EMBASE, and Web of Science databases to identify all relevant publications. The QUADAS-2 tool was implemented to assess the risk of bias and applicability concerns of each included study. The initial literature search yielded 483 publications. Thirteen articles were included. Articles were categorized into three groups: nine articles concerning primary diagnosis or staging, one article about tumor response to treatment, and three articles regarding scan techniques. In exocrine pancreatic tumors, measurements of blood flow in eight studies and blood volume in seven studies were significantly lower in tumor tissue, compared with measurements in pancreatic tissue outside of tumor, or normal pancreatic tissue in control groups of healthy volunteers. The studies were heterogeneous in the number of patients enrolled and scan protocols. Perfusion parameters measured and analyzed by DCE-CT might be useful in the investigation of characteristic vascular patterns of exocrine pancreatic tumors. Further clinical studies are desired for investigating the potential of DCE-CT in pancreatic tumors.

KW - disease, health science and nursing

KW - DCE-CT

KW - diagnostics

KW - pancreatic cancer

KW - scan techniques

KW - treatment response

UR - https://www.scopus.com/pages/publications/85050321484

U2 - 10.3390/diagnostics6030034

DO - 10.3390/diagnostics6030034

M3 - Review article

SN - 2075-4418

VL - 6

SP - 34

JO - Diagnostics

JF - Diagnostics

IS - 3

M1 - 34

ER -

Dynamic contrast-enhanced CT in patients with pancreatic cancer

Abstract

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