TY - JOUR
T1 - Establishment of patient‑derived lung tumorspheres and their response to internal irradiation by Auger electrons
AU - Madsen, Karina Lindbøg
AU - Langkjær, Niels
AU - Gerke, Oke
AU - Høilund-Carlsen, Poul
AU - Olsen, Birgitte Brinkmann
PY - 2022/3
Y1 - 2022/3
N2 - The high recurrence rate of lung cancer is a major clinical challenge associated with therapy‑resistant cancer stem cells (CSCs), which are rare subpopulations. Future successful treatment is required to also eradicate these subpopulations. Furthermore, the majority of anti‑cancer treatments are being tested in adherent monolayer cultures with the limitations this entails in the translation of results into clinical practice. The present study aimed to establish and characterize patient‑derived long‑term primary lung cancer tumorspheres enriched in CSCs and evaluate the effects of Auger electrons on them. These electrons are emitted from radionuclides that decay by electron capture or internal conversion and have demonstrated promising therapeutic potential. Their low energy (
AB - The high recurrence rate of lung cancer is a major clinical challenge associated with therapy‑resistant cancer stem cells (CSCs), which are rare subpopulations. Future successful treatment is required to also eradicate these subpopulations. Furthermore, the majority of anti‑cancer treatments are being tested in adherent monolayer cultures with the limitations this entails in the translation of results into clinical practice. The present study aimed to establish and characterize patient‑derived long‑term primary lung cancer tumorspheres enriched in CSCs and evaluate the effects of Auger electrons on them. These electrons are emitted from radionuclides that decay by electron capture or internal conversion and have demonstrated promising therapeutic potential. Their low energy (
U2 - 10.3892/ijo.2022.5324
DO - 10.3892/ijo.2022.5324
M3 - Journal article
SN - 1019-6439
JO - International Journal of Oncology
JF - International Journal of Oncology
ER -