Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould

Soumyaranjan Mohanty; Ioannis Mantis; Aradhya Mallikarjunaiah Chetan; Layla Bashir Larsen; Martin Dufva; Jenny Emnéus; Anders Wolff

Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould

Soumyaranjan Mohanty
, Ioannis Mantis
, Aradhya Mallikarjunaiah Chetan
, Layla Bashir Larsen
, Martin Dufva
, Jenny Emnéus
, Anders Wolff

Technical University of Denmark

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution to proceeding › peer-review

Abstract

We present a new scalable and general approach for manufacturing structured pores/channels in 3D polymer based scaffolds. The method involves 3D printing of a sacrificial polyvinyl alcohol (PVA) mould whose geometrical features are designed according to the required vascular channel network. Polydimethylsiloxane (PDMS) polymer is cast around the PVA mould, cross-linked and then the mould is dissolved, leaving behind a structured porous PDMS scaffold. The fabrication method described here is demonstrated with silicone elastomer but various other natural and synthetic polymers are compatible with this fabrication technique

Original language	English
Title of host publication	MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Number of pages	3
Publication date	2015
Pages	1439-1441
ISBN (Electronic)	9780979806483
Publication status	Published - 2015
Externally published	Yes
Event	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Hwabaek International Convention Center, Gyeongju-si, Korea, Republic of Duration: 25 Oct 2015 → 29 Oct 2015 Conference number: 19 https://mtas.hdasan.com/

Conference

Conference	19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Number	19
Location	Hwabaek International Convention Center
Country/Territory	Korea, Republic of
City	Gyeongju-si
Period	25/10/15 → 29/10/15
Internet address	https://mtas.hdasan.com/

Keywords

3D printing
Bioreactor
Elastomeric
Scaffold

Cite this

Mohanty, S., Mantis, I., Chetan, A. M., Larsen, L. B., Dufva, M., Emnéus, J., & Wolff, A. (2015). Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1439-1441)

Mohanty, Soumyaranjan ; Mantis, Ioannis ; Chetan, Aradhya Mallikarjunaiah et al. / Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould. MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2015. pp. 1439-1441

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title = "Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould",

abstract = "We present a new scalable and general approach for manufacturing structured pores/channels in 3D polymer based scaffolds. The method involves 3D printing of a sacrificial polyvinyl alcohol (PVA) mould whose geometrical features are designed according to the required vascular channel network. Polydimethylsiloxane (PDMS) polymer is cast around the PVA mould, cross-linked and then the mould is dissolved, leaving behind a structured porous PDMS scaffold. The fabrication method described here is demonstrated with silicone elastomer but various other natural and synthetic polymers are compatible with this fabrication technique",

keywords = "3D printing, Bioreactor, Elastomeric, Scaffold",

author = "Soumyaranjan Mohanty and Ioannis Mantis and Chetan, \{Aradhya Mallikarjunaiah\} and Larsen, \{Layla Bashir\} and Martin Dufva and Jenny Emn{\'e}us and Anders Wolff",

note = "Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",

year = "2015",

language = "English",

pages = "1439--1441",

booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

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Mohanty, S, Mantis, I, Chetan, AM, Larsen, LB, Dufva, M, Emnéus, J & Wolff, A 2015, Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould. in MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. pp. 1439-1441, 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Gyeongju-si, Korea, Republic of, 25/10/15.

Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould. / Mohanty, Soumyaranjan; Mantis, Ioannis; Chetan, Aradhya Mallikarjunaiah et al.
MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2015. p. 1439-1441.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution to proceeding › peer-review

TY - GEN

T1 - Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould

AU - Mohanty, Soumyaranjan

AU - Mantis, Ioannis

AU - Chetan, Aradhya Mallikarjunaiah

AU - Larsen, Layla Bashir

AU - Dufva, Martin

AU - Emnéus, Jenny

AU - Wolff, Anders

N1 - Conference code: 19

PY - 2015

Y1 - 2015

N2 - We present a new scalable and general approach for manufacturing structured pores/channels in 3D polymer based scaffolds. The method involves 3D printing of a sacrificial polyvinyl alcohol (PVA) mould whose geometrical features are designed according to the required vascular channel network. Polydimethylsiloxane (PDMS) polymer is cast around the PVA mould, cross-linked and then the mould is dissolved, leaving behind a structured porous PDMS scaffold. The fabrication method described here is demonstrated with silicone elastomer but various other natural and synthetic polymers are compatible with this fabrication technique

AB - We present a new scalable and general approach for manufacturing structured pores/channels in 3D polymer based scaffolds. The method involves 3D printing of a sacrificial polyvinyl alcohol (PVA) mould whose geometrical features are designed according to the required vascular channel network. Polydimethylsiloxane (PDMS) polymer is cast around the PVA mould, cross-linked and then the mould is dissolved, leaving behind a structured porous PDMS scaffold. The fabrication method described here is demonstrated with silicone elastomer but various other natural and synthetic polymers are compatible with this fabrication technique

KW - 3D printing

KW - Bioreactor

KW - Elastomeric

KW - Scaffold

M3 - Conference contribution to proceeding

SP - 1439

EP - 1441

BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 25 October 2015 through 29 October 2015

ER -

Mohanty S, Mantis I, Chetan AM, Larsen LB, Dufva M, Emnéus J et al. Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2015. p. 1439-1441

Fabrication of Three Dimensional Tissue Engineering Polydimethylsiloxane ( PDMS) Microporous Scaffolds Integrated in a Bioreactor Using a 3D Printed Water Dissolvable Sacrificial Mould

Abstract

Conference

Keywords

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Cite this