Glucose turnover at whole-body and skeletal muscle level in response to parenteral nutrition in male patients with alcoholic liver cirrhosis

Beckey Trinh, Anders Rinnov, Ulrik Winning Iepsen, Gregers Winding Munch, Kamilla Munch Winding, Carsten Ammitzbøl Lauridsen, Lise Lotte Glud, Gerrit van Hal, Bente Klarlund Pedersen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Background & aims
Cirrhosis is associated with insulin resistance and impaired glucose tolerance, which may be caused by impairments at different tissue levels (liver, skeletal muscle, and/or beta cell).
Methods
Here, glucose kinetics at whole-body and skeletal muscle level in patients with cirrhosis (Child-Pugh A and B) were studied during parenteral nutrition using the isotope dilution technique and arteriovenous balance approach across the leg. As opposed to the euglycemic hyperinsulinemic clamp or glucose tolerance tests applied in previous studies, this approach provides a nutrient composition more similar to a normal meal while circumventing any possible portal-systemic shunting, impaired hepatic uptake and incretin effect.
Results
We confirmed the presence of hepatic and peripheral insulin resistance in our patient population. Endogenous glucose production was less suppressed in response to parenteral nutrition. However, glucose uptake in skeletal muscle was increased.
Conclusion
Our results suggests that in our study participants with cirrhosis, the hepatic and peripheral insulin resistance is compensated for by increased insulin secretion and thus, increased glucose uptake in muscle. Hereby, glucose homeostasis is maintained.
Original languageEnglish
JournalAmerican Journal of Physiology
Volume60
Pages (from-to)240-246
Number of pages7
ISSN0002-9513
DOIs
Publication statusPublished - Apr 2024

Keywords

  • chronically ill
  • radiography

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