Glycan-mediated modification of the immune response

Caroline Benedicte Kjærulff Mathiesen; Anders Elm Pedersen; Hans H. Wandall

doi:10.4161/onci.23659

Glycan-mediated modification of the immune response

Caroline Benedicte Kjærulff Mathiesen
, Anders Elm Pedersen
, Hans H. Wandall

University of Copenhagen

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

Original language	English
Article number	e23659
Journal	Oncoimmunology
Volume	2
Issue number	4
Pages (from-to)	e23659
ISSN	2162-4011
DOIs	https://doi.org/10.4161/onci.23659
Publication status	Published - Apr 2013
Externally published	Yes

Keywords

clinical assessment methods, lab technology and radiography
C-type lectins
GalNAc
carbohydrate receptors
dendritic cells
glycans
vaccines

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10.4161/onci.23659Licence: CC BY

Cite this

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title = "Glycan-mediated modification of the immune response",

abstract = "Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.",

keywords = "clinical assessment methods, lab technology and radiography, C-type lectins, GalNAc, carbohydrate receptors, dendritic cells, glycans, vaccines",

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AB - Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4+ T-cell and humoral responses, but prevents CD8+ T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

KW - clinical assessment methods, lab technology and radiography

KW - C-type lectins

KW - GalNAc

KW - carbohydrate receptors

KW - dendritic cells

KW - glycans

KW - vaccines

U2 - 10.4161/onci.23659

DO - 10.4161/onci.23659

M3 - Journal article

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Glycan-mediated modification of the immune response

Abstract

Keywords

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