Abstract
Purpose:
Some healthcare professionals are exposed to low-dose ionizing radiation. While high-dose radiation is an established carcinogen, uncertainty remains regarding long-term cancer risks associated with sustained low-dose occupational exposure. This study aims to quantify the association between cumulative occupational radiation dose and cancer incidence among healthcare professionals, as well as other selected non-malignant outcomes.
Methods:
This nationwide register-based cohort study includes healthcare professionals who have carried personal radiation dosimeters since 1967, identified through the Danish Health Authority’s Registry of Personal Dosimetry. Individual cumulative dose histories are linked via the Danish Civil Registration Number to national registries, including the Danish Cancer Registry, National Patient Register, and socioeconomic databases.
Three comparator cohorts are established: (1) non-exposed healthcare professionals matched on education/specialty, age, and sex; (2) general population controls matched on education, age, and sex; and (3) general population controls matched on age and sex. Pathology incidence and site-specific risks will be analysed using hazard ratios and competing risk models, with dose–response analyses based on cumulative exposure.
Results:
Data linkage and cohort construction are ongoing. Planned analyses will describe exposure distributions and estimate disease risks associated with cumulative occupational radiation exposure.
Conclusion:
By linking long-term individual dosimetry data with comprehensive national registries, this study will provide robust evidence on cancer risk and broader health effects related to occupational low-dose radiation exposure, informing radiation protection and occupational health policies.
Some healthcare professionals are exposed to low-dose ionizing radiation. While high-dose radiation is an established carcinogen, uncertainty remains regarding long-term cancer risks associated with sustained low-dose occupational exposure. This study aims to quantify the association between cumulative occupational radiation dose and cancer incidence among healthcare professionals, as well as other selected non-malignant outcomes.
Methods:
This nationwide register-based cohort study includes healthcare professionals who have carried personal radiation dosimeters since 1967, identified through the Danish Health Authority’s Registry of Personal Dosimetry. Individual cumulative dose histories are linked via the Danish Civil Registration Number to national registries, including the Danish Cancer Registry, National Patient Register, and socioeconomic databases.
Three comparator cohorts are established: (1) non-exposed healthcare professionals matched on education/specialty, age, and sex; (2) general population controls matched on education, age, and sex; and (3) general population controls matched on age and sex. Pathology incidence and site-specific risks will be analysed using hazard ratios and competing risk models, with dose–response analyses based on cumulative exposure.
Results:
Data linkage and cohort construction are ongoing. Planned analyses will describe exposure distributions and estimate disease risks associated with cumulative occupational radiation exposure.
Conclusion:
By linking long-term individual dosimetry data with comprehensive national registries, this study will provide robust evidence on cancer risk and broader health effects related to occupational low-dose radiation exposure, informing radiation protection and occupational health policies.
| Original language | English |
|---|---|
| Publication date | Jun 2026 |
| Publication status | Published - Jun 2026 |
| Event | Japanese Scandinavian Radiological Society - Tivoli Hotel & Congress Center, København, Denmark Duration: 2 Jun 2026 → 4 Jun 2026 Conference number: 16 http://www.jsrs.dk/index.html |
Conference
| Conference | Japanese Scandinavian Radiological Society |
|---|---|
| Number | 16 |
| Location | Tivoli Hotel & Congress Center |
| Country/Territory | Denmark |
| City | København |
| Period | 02/06/26 → 04/06/26 |
| Internet address |
Projects
- 1 Active
-
SIRT: Safety in Imaging and Radiation Treatment
Brage, K. (Principle researcher), Hansen, P. L. (CoPI), Brage, O. (Co-researcher), Precht, H. (Co-researcher), hansen, D. L. (Co-researcher), Eklund Nygaard, D. (Co-researcher), Möller, S. (Co-researcher), Skjøth, F. (Co-researcher), Waltenburg, H. (Co-researcher), Bangsgaard, J. P. (Co-researcher), Ravnsborg Beierholm, A. (Co-researcher), Frederiksen, H. (Co-researcher), Kold Jensen, T. (Co-researcher), Bernier, M. O. (Co-researcher) & Baudin, C. (Principle researcher)
01/12/22 → 01/12/27
Project: Research
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