Prediction of preeclampsia by a combination of cell-free fetal hemoglobin, cell-free fetal DNA and maternal obstetric history

Leif Kofoed Nielsen; Tanja Roien Jakobsen; Sharri Junadi Mortensen; Steen Ladelund; Klaus Rieneck; Frederik Banch Clausen; Jens René Bundgaard; Morten Hanefeld Dziegiel

doi:10.1101/2025.03.30.25324756

Prediction of preeclampsia by a combination of cell-free fetal hemoglobin, cell-free fetal DNA and maternal obstetric history

Leif Kofoed Nielsen
, Tanja Roien Jakobsen
, Sharri Junadi Mortensen
, Steen Ladelund
, Klaus Rieneck
, Frederik Banch Clausen
, Jens René Bundgaard
, Morten Hanefeld Dziegiel

Copenhagen University Hospital
Copenhagen University Hospital - Hvidovre

Research output: Working paper/preprint › Preprint

Abstract

The aim of the study was to investigate the combination of cell-free fetal hemoglobin (cfHbF), total cell-free hemoglobin (tcfHb), cell-free fetal DNA (cffDNA), Pregnancy Associated Plasma Protein A (PAPP-A) and maternal obstetric history as potential markers in first and second trimester, for prediction of preeclampsia (PE) in asymptomatic pregnant women.

Original language	English
Publisher	medRxiv
Number of pages	23
DOIs	https://doi.org/10.1101/2025.03.30.25324756
Publication status	Published - 1 Apr 2025

Keywords

clinical assessment methods, lab technology and radiography

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10.1101/2025.03.30.25324756

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abstract = "The aim of the study was to investigate the combination of cell-free fetal hemoglobin (cfHbF), total cell-free hemoglobin (tcfHb), cell-free fetal DNA (cffDNA), Pregnancy Associated Plasma Protein A (PAPP-A) and maternal obstetric history as potential markers in first and second trimester, for prediction of preeclampsia (PE) in asymptomatic pregnant women.",

keywords = "clinical assessment methods, lab technology and radiography",

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AU - Nielsen, Leif Kofoed

AU - Jakobsen, Tanja Roien

AU - Mortensen, Sharri Junadi

AU - Ladelund, Steen

AU - Rieneck, Klaus

AU - Clausen, Frederik Banch

AU - Bundgaard, Jens René

AU - Dziegiel, Morten Hanefeld

PY - 2025/4/1

Y1 - 2025/4/1

N2 - The aim of the study was to investigate the combination of cell-free fetal hemoglobin (cfHbF), total cell-free hemoglobin (tcfHb), cell-free fetal DNA (cffDNA), Pregnancy Associated Plasma Protein A (PAPP-A) and maternal obstetric history as potential markers in first and second trimester, for prediction of preeclampsia (PE) in asymptomatic pregnant women.

AB - The aim of the study was to investigate the combination of cell-free fetal hemoglobin (cfHbF), total cell-free hemoglobin (tcfHb), cell-free fetal DNA (cffDNA), Pregnancy Associated Plasma Protein A (PAPP-A) and maternal obstetric history as potential markers in first and second trimester, for prediction of preeclampsia (PE) in asymptomatic pregnant women.

KW - clinical assessment methods, lab technology and radiography

U2 - 10.1101/2025.03.30.25324756

DO - 10.1101/2025.03.30.25324756

M3 - Preprint

BT - Prediction of preeclampsia by a combination of cell-free fetal hemoglobin, cell-free fetal DNA and maternal obstetric history

PB - medRxiv

ER -

Prediction of preeclampsia by a combination of cell-free fetal hemoglobin, cell-free fetal DNA and maternal obstetric history

Abstract

Keywords

Access to Document

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