Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants

Steffan Wittrup McPhee Christensen; Edith Lorena Elgueta Cancino; Morten Bilde Simonsen; P. Silva; Line Bay Sørensen; Thomas Graven-Nielsen; Rogério Hirata

Abstract

Background and aims: Neck pain is one of the most prevalent musculoskeletal problems. Those suffering from persistent neck pain may have a reduced exercise-induced hypoalgesic (EIH) or even a hyperalgesic response, opposite to what is seen in healthy populations.
The aim of this study was to investigate EIH in a healthy population following the onset of prolonged experimental neck pain.

Methods: Forty healthy participants were randomized to receive 0.5ml injections with Nerve Growth Factor (NFG) (5 μg) or isotonic saline (0.9%) into the right splenius capitis muscle on days 0 and 2. Disability due to neck pain was assessed using the Neck Disability Index (NDI). Pressure Pain Thresholds (PPTs) were recorded bilaterally over splenius capitis (neck), temporalis (head) and tibialis anterior (leg) muscles. This was done before and after a progressive exercise protocol using an arm crank ergometer on days 0, 4 and 15. EIH was expressed as the pre-exercise PPT subtracted from the post-exercise PPT.

Results: The NGF group displayed higher NDI scores on day 2 and 4 compared the control group (P<0.01).
For the neck site the control group had a greater EIH compared to the NGF group (P<0.01). For both the head and leg site the control group showed increased EIH at day 4 and 15 (P<0.05) compared to the NGF group.

Conclusions: The results indicate that even a few days with neck pain can impact EIH response. These results may help explain why some neck pain patients experience exacerbation of their symptoms during exercise.

Original language	English
Publication date	Apr 2022
Publication status	Published - Apr 2022
Event	12th Congress of the European Pain Federation: Pain in Europe XII - Dublin, Ireland Duration: 27 Apr 2022 → 30 Apr 2022 Conference number: 12 https://efic-congress.org/efic2022-welcome-messages/

Conference

Conference	12th Congress of the European Pain Federation
Number	12
Country/Territory	Ireland
City	Dublin
Period	27/04/22 → 30/04/22
Other	12th Congress of the European Pain Federation (EFIC 2022) is dedicated to scientfic application of clinical pain management and how best can pain treatment be applied in future, covering multidisciplinary aspects of research and medical practice in the ...
Internet address	https://efic-congress.org/efic2022-welcome-messages/

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Christensen, S. W. M., Cancino, E. L. E., Simonsen, M. B., Silva, P., Sørensen, L. B., Graven-Nielsen, T., & Hirata, R. (2022). Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants. Abstract from 12th Congress of the European Pain Federation, Dublin, Ireland. https://efic2022.abstractserver.com/program/#/details/presentations/871

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title = "Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants",

abstract = "Background and aims: Neck pain is one of the most prevalent musculoskeletal problems. Those suffering from persistent neck pain may have a reduced exercise-induced hypoalgesic (EIH) or even a hyperalgesic response, opposite to what is seen in healthy populations. The aim of this study was to investigate EIH in a healthy population following the onset of prolonged experimental neck pain. Methods: Forty healthy participants were randomized to receive 0.5ml injections with Nerve Growth Factor (NFG) (5 μg) or isotonic saline (0.9\%) into the right splenius capitis muscle on days 0 and 2. Disability due to neck pain was assessed using the Neck Disability Index (NDI). Pressure Pain Thresholds (PPTs) were recorded bilaterally over splenius capitis (neck), temporalis (head) and tibialis anterior (leg) muscles. This was done before and after a progressive exercise protocol using an arm crank ergometer on days 0, 4 and 15. EIH was expressed as the pre-exercise PPT subtracted from the post-exercise PPT. Results: The NGF group displayed higher NDI scores on day 2 and 4 compared the control group (P<0.01). For the neck site the control group had a greater EIH compared to the NGF group (P<0.01). For both the head and leg site the control group showed increased EIH at day 4 and 15 (P<0.05) compared to the NGF group. Conclusions: The results indicate that even a few days with neck pain can impact EIH response. These results may help explain why some neck pain patients experience exacerbation of their symptoms during exercise.",

author = "Christensen, \{Steffan Wittrup McPhee\} and Cancino, \{Edith Lorena Elgueta\} and Simonsen, \{Morten Bilde\} and P. Silva and S{\o}rensen, \{Line Bay\} and Thomas Graven-Nielsen and Rog{\'e}rio Hirata",

year = "2022",

month = apr,

language = "English",

note = "12th Congress of the European Pain Federation : Pain in Europe XII, EFIC2022 ; Conference date: 27-04-2022 Through 30-04-2022",

url = "https://efic-congress.org/efic2022-welcome-messages/",

}

Christensen, SWM, Cancino, ELE, Simonsen, MB, Silva, P, Sørensen, LB, Graven-Nielsen, T & Hirata, R 2022, 'Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants', 12th Congress of the European Pain Federation, Dublin, Ireland, 27/04/22 - 30/04/22. <https://efic2022.abstractserver.com/program/#/details/presentations/871>

Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants. / Christensen, Steffan Wittrup McPhee; Cancino, Edith Lorena Elgueta; Simonsen, Morten Bilde et al.
2022. Abstract from 12th Congress of the European Pain Federation, Dublin, Ireland.

Research output: Contribution to conference without a publisher/journal › Abstract › Research › peer-review

TY - ABST

T1 - Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants

AU - Christensen, Steffan Wittrup McPhee

AU - Cancino, Edith Lorena Elgueta

AU - Simonsen, Morten Bilde

AU - Silva, P.

AU - Sørensen, Line Bay

AU - Graven-Nielsen, Thomas

AU - Hirata, Rogério

N1 - Conference code: 12

PY - 2022/4

Y1 - 2022/4

N2 - Background and aims: Neck pain is one of the most prevalent musculoskeletal problems. Those suffering from persistent neck pain may have a reduced exercise-induced hypoalgesic (EIH) or even a hyperalgesic response, opposite to what is seen in healthy populations. The aim of this study was to investigate EIH in a healthy population following the onset of prolonged experimental neck pain. Methods: Forty healthy participants were randomized to receive 0.5ml injections with Nerve Growth Factor (NFG) (5 μg) or isotonic saline (0.9%) into the right splenius capitis muscle on days 0 and 2. Disability due to neck pain was assessed using the Neck Disability Index (NDI). Pressure Pain Thresholds (PPTs) were recorded bilaterally over splenius capitis (neck), temporalis (head) and tibialis anterior (leg) muscles. This was done before and after a progressive exercise protocol using an arm crank ergometer on days 0, 4 and 15. EIH was expressed as the pre-exercise PPT subtracted from the post-exercise PPT. Results: The NGF group displayed higher NDI scores on day 2 and 4 compared the control group (P<0.01). For the neck site the control group had a greater EIH compared to the NGF group (P<0.01). For both the head and leg site the control group showed increased EIH at day 4 and 15 (P<0.05) compared to the NGF group. Conclusions: The results indicate that even a few days with neck pain can impact EIH response. These results may help explain why some neck pain patients experience exacerbation of their symptoms during exercise.

AB - Background and aims: Neck pain is one of the most prevalent musculoskeletal problems. Those suffering from persistent neck pain may have a reduced exercise-induced hypoalgesic (EIH) or even a hyperalgesic response, opposite to what is seen in healthy populations. The aim of this study was to investigate EIH in a healthy population following the onset of prolonged experimental neck pain. Methods: Forty healthy participants were randomized to receive 0.5ml injections with Nerve Growth Factor (NFG) (5 μg) or isotonic saline (0.9%) into the right splenius capitis muscle on days 0 and 2. Disability due to neck pain was assessed using the Neck Disability Index (NDI). Pressure Pain Thresholds (PPTs) were recorded bilaterally over splenius capitis (neck), temporalis (head) and tibialis anterior (leg) muscles. This was done before and after a progressive exercise protocol using an arm crank ergometer on days 0, 4 and 15. EIH was expressed as the pre-exercise PPT subtracted from the post-exercise PPT. Results: The NGF group displayed higher NDI scores on day 2 and 4 compared the control group (P<0.01). For the neck site the control group had a greater EIH compared to the NGF group (P<0.01). For both the head and leg site the control group showed increased EIH at day 4 and 15 (P<0.05) compared to the NGF group. Conclusions: The results indicate that even a few days with neck pain can impact EIH response. These results may help explain why some neck pain patients experience exacerbation of their symptoms during exercise.

UR - https://vbn.aau.dk/en/publications/f897491e-15ee-4d5f-a889-9d64486cabbe

M3 - Abstract

T2 - 12th Congress of the European Pain Federation

Y2 - 27 April 2022 through 30 April 2022

ER -

Prolonged experimental neck pain impair efficacy of exercise-induced hypoalgesia in healthy participants

Abstract

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