Protein Kvalitetskontrol i det endoplasmatiske reticulum

Malene Munk Jørgensen, Peter Bross, Niels Gregersen

Research output: Contribution to journalJournal articleResearch

Abstract

Protein folding and quality control in the endoplasmic reticulum (ER) are synchronized mechanisms ensuring that only properly folded proteins are intergrated in the plasma membrane or secreted from the cell. These mechanisms act in close collaboration with the molecular machinery involved in retrograde-translocation and degradation of non-native proteins and with the ER-stress activated sinalling system. The common goal of these mechanisms is to prevent ecpression and secretion of misfolded proteins. Protein misfolding can be detrimental to the cell and contributes to the disease mechanism in severeal inherited disorders, e.g. cystic fibrosis, familial hypercholesterolemia and diabetes insipididus. This review outlines the molecular mechanisms in protein quality control occuring in the ER, signalling caused by ER stress, and finally ER associated protein degradation.
Translated title of the contributionProtein Kvalitetskontrol i det endoplasmatiske reticulum
Original languageDanish
Article number12874956
JournalAPMIS
Volume111
Issue number109
Pages (from-to)86-91
Number of pages6
ISSN1600-0463
Publication statusPublished - 2003

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