The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

Emilie L Henriksen; Jonathan F Carlsen; Ilse Mm Vejborg; Michael B Nielsen; Carsten A Lauridsen

doi:10.1177/0284185118770917

The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

Emilie L Henriksen
, Jonathan F Carlsen
, Ilse Mm Vejborg
, Michael B Nielsen
, Carsten A Lauridsen

Copenhagen University Hospital
Metropol EVU

Research output: Contribution to journal › Review article › peer-review

Abstract

BACKGROUND: Early detection of breast cancer (BC) is crucial in lowering the mortality.

PURPOSE: To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD.

MATERIAL AND METHODS: PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included.

RESULTS: All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR.

CONCLUSION: All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.

Original language	English
Journal	Acta Radiologica
Volume	60
Issue number	1
Pages (from-to)	13-18
Number of pages	6
ISSN	0284-1851
DOIs	https://doi.org/10.1177/0284185118770917
Publication status	Published - 1 Jan 2019

Keywords

Breast Neoplasms/diagnostic imaging
Breast/diagnostic imaging
Early Detection of Cancer/methods
Female
Humans
Mammography/methods
Radiographic Image Interpretation, Computer-Assisted/methods
Reproducibility of Results
Sensitivity and Specificity

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10.1177/0284185118770917

Cite this

@article{088353e9dc5f493387eba9be14c75604,

title = "The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review",

abstract = "BACKGROUND: Early detection of breast cancer (BC) is crucial in lowering the mortality.PURPOSE: To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD.MATERIAL AND METHODS: PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included.RESULTS: All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR.CONCLUSION: All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.",

keywords = "Breast Neoplasms/diagnostic imaging, Breast/diagnostic imaging, Early Detection of Cancer/methods, Female, Humans, Mammography/methods, Radiographic Image Interpretation, Computer-Assisted/methods, Reproducibility of Results, Sensitivity and Specificity",

author = "Henriksen, \{Emilie L\} and Carlsen, \{Jonathan F\} and Vejborg, \{Ilse Mm\} and Nielsen, \{Michael B\} and Lauridsen, \{Carsten A\}",

note = "Publisher Copyright: {\textcopyright} The Foundation Acta Radiologica 2018.",

year = "2019",

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doi = "10.1177/0284185118770917",

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volume = "60",

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journal = "Acta Radiologica",

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T1 - The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening

T2 - a systematic review

AU - Henriksen, Emilie L

AU - Carlsen, Jonathan F

AU - Vejborg, Ilse Mm

AU - Nielsen, Michael B

AU - Lauridsen, Carsten A

N1 - Publisher Copyright: © The Foundation Acta Radiologica 2018.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - BACKGROUND: Early detection of breast cancer (BC) is crucial in lowering the mortality.PURPOSE: To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD.MATERIAL AND METHODS: PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included.RESULTS: All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR.CONCLUSION: All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.

AB - BACKGROUND: Early detection of breast cancer (BC) is crucial in lowering the mortality.PURPOSE: To present an overview of studies concerning computer-aided detection (CAD) in screening mammography for early detection of BC and compare diagnostic accuracy and recall rates (RR) of single reading (SR) with SR + CAD and double reading (DR) with SR + CAD.MATERIAL AND METHODS: PRISMA guidelines were used as a review protocol. Articles on clinical trials concerning CAD for detection of BC in a screening population were included. The literature search resulted in 1522 records. A total of 1491 records were excluded by abstract and 18 were excluded by full text reading. A total of 13 articles were included.RESULTS: All but two studies from the SR vs. SR + CAD group showed an increased sensitivity and/or cancer detection rate (CDR) when adding CAD. The DR vs. SR + CAD group showed no significant differences in sensitivity and CDR. Adding CAD to SR increased the RR and decreased the specificity in all but one study. For the DR vs. SR + CAD group only one study reported a significant difference in RR.CONCLUSION: All but two studies showed an increase in RR, sensitivity and CDR when adding CAD to SR. Compared to DR no statistically significant differences in sensitivity or CDR were reported. Additional studies based on organized population-based screening programs, with longer follow-up time, high-volume readers, and digital mammography are needed to evaluate the efficacy of CAD.

KW - Breast Neoplasms/diagnostic imaging

KW - Breast/diagnostic imaging

KW - Early Detection of Cancer/methods

KW - Female

KW - Humans

KW - Mammography/methods

KW - Radiographic Image Interpretation, Computer-Assisted/methods

KW - Reproducibility of Results

KW - Sensitivity and Specificity

UR - https://www.scopus.com/pages/publications/85045851566

U2 - 10.1177/0284185118770917

DO - 10.1177/0284185118770917

M3 - Review article

C2 - 29665706

SN - 0284-1851

VL - 60

SP - 13

EP - 18

JO - Acta Radiologica

JF - Acta Radiologica

IS - 1

ER -

The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

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